CogNano¥Ó¥Ã¥¯¥é¥¤¥Ö¥é¥ê¡¼VHH
¡Èº£¤Þ¤Ç¤Ê¤«¤Ã¤¿¡ÉÁÏÌô¥·¡¼¥º¤ò¤ªÃµ¤·¤ÎÊý¤Ø¡¡º£¤Þ¤ÇÄü¤á¤Æ¤¤¤¿¥ì¥¢¥¯¥í¡¼¥óȯ¸«
CogNano¥Ó¥Ã¥¯¥é¥¤¥Ö¥é¥ê¡¼¤Ë¤è¤ë¿ÍÍÀ¤Î¤¢¤ë¿¤¯¤Î¥¯¥í¡¼¥ó¤«¤é¡¢CogNanoÆȼ«¤ÎAI¤Ç·¡¤ê½Ð¤¹¤³¤È¤¬²Äǽ¤Ç¤¹¡£
³×¿·Åª¤Ê¸¦µæ¤Î·ë²Ì¡ØTriple negativeÆý¤¬¤ó¡ÊTNBC¡Ë¤Ç2000Ëü¥¯¥í¡¼¥ó¤«¤é12¥¯¥í¡¼¥ó¤Î¥Þ¡¼¥«¡¼¸õÊä¤ò¸«¤Ä¤±¤Þ¤·¤¿¡Ù¡öÉÂÍýÀ÷¿§²èÁü¤â¤´¤¶¤¤¤Þ¤¹¡£¤ªÌä¹ç¤»¤¯¤À¤µ¤¤¡£
̤¤À¥Þ¡¼¥«¡¼¤¬¸«¤Ä¤«¤Ã¤Æ¤¤¤Ê¤¤¡¢ÃΤé¤ì¤Æ¤¤¤Ê¤¤Â¾¤Î¥¬¥ó¤ÎDirect¥Þ¡¼¥«¡¼¤òÍѤ¤¤¿ÁÏÌô¤Ë¡ÊÇÙ´â(¾®ºÙ˦´â¡Ëç¹´â¤äÃÀ´É´â¤âDirect¥Þ¡¼¥«¡¼³«È¯Ãæ¤Ç¤¹¡Ë
CogNano¤Î¥Ó¥Ã¥¯¥é¥¤¥Ö¥é¥ê¡¼VHH¤Ê¤é¡¢°µÅÝŪ¤Ê¿ô¤ÎɸŪ·ë¹ç¥¯¥í¡¼¥ó¤Î¤Ê¤«¤«¤é¡¢¤ªË¾¤ß¤ÎÁÏÌô¥·¡¼¥º¤ò·×»»²Ê³Ø¤Çȯ·¡¤·¤Þ¤¹¡£¤³¤Î¤¿¤Ó¡¢¿··¿¥³¥í¥ÊÊÑ°Û·¿(VOC)½Ð¸½Á°¤«¤é¡¢¥ª¥ß¥¯¥í¥ó³ôBA.2¤Ë¤âÄÌÍѤ¹¤ëÀ¤³¦¥È¥Ã¥×IC50¤Î¥·¡¼¥º¤òÄ󶡤·¤Æ¤¤¤¿¤³¤È¤¬ÏÃÂê¤È¤Ê¤Ã¤Æ¤¤¤Þ¤¹¡£¤³¤ì¤Ï¶öÁ³¤Î»ºÊª¤Ç¤Ï¤¢¤ê¤Þ¤»¤ó¡£
¿··¿¥³¥í¥Ê¥¦¥¤¥ë¥¹¤ò
ÃæϤ¹¤ë¥¢¥ë¥Ñ¥«¹³ÂÎ
¥ª¥ß¥¯¥í¥ó¤ò´Þ¤à
Á´¤Æ¤ÎÊÑ°Û³ô¤Ë͸ú
¢£Ê¸¸¥¢£
¡Journal: Cold Spring Harbor Laboratory, bioRxiv, THE PREPRINT SERVER FOR BIOLOGY
Title: Nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants
https://www.biorxiv.org/content/10.1101/2021.10.25.465714v1
¢Journal: Communications Biology.
DOI : 10.1038/s42003-022-03630-3
Title : A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron.
https://rdcu.be/cQ5Aq
¢£PRTIMESµ»ö(2022ǯ10·î15Æü10:00)¢£
https://prtimes.jp/main/html/rd/p/000000002.000104790.html
¢£CogNano¼ÒWeb-NEWS¢£
https://www.cognano.co.jp/2022/07/15/a-panel-of-nanobodies-recognizing-conserved-hidden-clefts-of-all-sars-cov-2-spike-variants-including-omicron/
- ¤³¤³¤¬¥Ý¥¤¥ó¥È£±¡§
¤Ê¤¼CogNano¤Ï¥¢¥ë¥Ñ¥«¤ò»ÈÍѤ·¤Æ¤¤¤ë¤Î¤«¡©
¥ï¥¯¥Á¥ó¤ò¼Â»Ü¤·¤¿¼«¼Ò¥¢¥ë¥Ñ¥«¤«¤é¡¢CogNano¼Ò¤ÎÆȼ«Ë¡¤ÇÌó1000²¯¥¯¥í¡¼¥ó¡Ê£±£°£±1¡Ë¤Î¿ÍÍÀ¤ËÉÙ¤ó¤ÀVHH¥Þ¥¶¡¼¥é¥¤¥Ö¥é¥ê¤¬ÆÀ¤é¤ì¤Þ¤¹¡£¥Õ¥¡¡¼¥¸¥Ç¥£¥¹¥×¥ì¥¤¤Ë¤è¤ê¡¢Í¸ú¤ÊɸŪ·ë¹ç¥¯¥í¡¼¥ó¤¬¿ôÀéËü¥¯¥í¡¼¥ó¡Ê£±£°£·¡ËÆÀ¤é¤ì¡¢NGS¡Ê¼¡À¤Â奷¡¼¥±¥ó¥¹¡Ë¤Ë°ú¤Â³¤¤¤Æ¥³¥ó¥Ô¥å¡¼¥¿²òÀϤò¤·¤Þ¤¹¡£¤·¤«¤·½¾Íè¤Ï¡¢À޳ѤΥޥ¶¡¼¥é¥¤¥Ö¥é¥ê¤«¤é¿ô½½¸Ä¡Á¿ôÉ´¼ïÎàÄøÅÙ¤ÎVHH¹³ÂΤò¥Ô¥Ã¥¯¥¢¥Ã¥×¤¹¤ë¤Þ¤Ç¤¬¸Â³¦¤Ç¤·¤¿¡£¤³¤ì¤Ç¤Ï¥Þ¥¦¥¹¤Î¥â¥Î¥¯¥í¥Ê¡¼¥ë¹³ÂΤÈƱ¤¸¸õÊä¿ô¤Ë¤Ê¤ê¡¢¥¢¥ë¥Ñ¥«¤ò»ÈÍѤ¹¤ë°ÕÌ£¤¬¤Ê¤¤¡¢Èó¾ï¤Ë¤â¤Ã¤¿¤¤¤Ê¤¤Î®¤ì¤Ç¤·¤¿¡£À¸¤¤¿¥¢¥ë¥Ñ¥«¤òÍѤ¤¤Ê¤¤¡Ö¥Ê¥¤¡¼¥Ö¥é¥¤¥Ö¥é¥êË¡¡×¤Ç¤Ï¡¢Ãµº÷ÈϰϤϤµ¤é¤Ë¶¹¤¯¤Ê¤ê¤Þ¤¹¡£
- ¤³¤³¤¬¥Ý¥¤¥ó¥È2¡§
¤Ê¤¼CogNano¤ÏNGS¤Þ¤Ç¶î»È¤·¤ÆÆÀ¤¿ÇüÂç¤Ê¹³ÂÎ¥¢¥ß¥Î»ÀÇÛÎó¡Ê¥Ó¥Ã¥°¥é¥¤¥Ö¥é¥ê¡Ë¤Çɾ²Á¤¹¤ë¤Î¤«¡©
NGS¤ÇËÄÂç¤Ê¥·¡¼¥±¥ó¥¹¥Ç¡¼¥¿¤¬ÆÀ¤é¤ì¤Æ¤â¡¢¸Ä¡¹¤Î¥¯¥í¡¼¥ó¤ÎÍÍÑÀ¤òÅŻҥǡ¼¥¿¤Î¤Þ¤Þɾ²Á¤¹¤ë»ö¤Ïº¤Æñ¤Ç¤·¤¿¡£CogNano¤Ï¡¢·ÏÅý¼ù²òÀÏ¡¦¥Ñ¥¿¡¼¥óǧ¼±¡¦µ¡³£³Ø½¬¤ò¶î»È¤·¤Æɾ²Á³ÎΨ¤ò¹â¤á¤ë¥¢¥ë¥´¥ê¥º¥à¤ò³«È¯¤·¤Þ¤·¤¿¡Ê½Ð´êÃæ¡Ë¡£¤³¤Î¥¢¥ë¥´¥ê¥º¥à²òÀϤËÀ®¸ù¤·¤Æ½é¤á¤Æ¥Ó¥Ã¥°¥é¥¤¥Ö¥é¥ê¤ò͸úÍøÍѤǤ¤ë¤³¤È¤Ë¤Ê¤ê¤Þ¤¹¡£¤³¤ì¤Ë¤è¤ê¡¢»Ë¾å½é¤á¤Æ¡¢¿ôÀéËü¼ïÎà¤Î¹³ÂθõÊä¤ÎÃ椫¤é¡¢µ©¾¯¤ÇÍÍѤʹ³ÂΤò·¡¤ê½Ð¤¹¤³¤È¤¬²Äǽ¤Ë¤Ê¤ê¤Þ¤·¤¿¡£
- ¤³¤³¤¬¥Ý¥¤¥ó¥È3¡§
¤Ê¤¼CogNano¤Ï¿··¿¥³¥í¥ÊÊÑ°Û³ô½Ð¸½Á°¤Ë¡¢¥ª¥ß¥¯¥í¥óÃæÏÂ¥¯¥í¡¼¥ó¤òȯ·¡¤Ç¤¤Æ¤¤¤¿¤Î¤«¡©
CogNano¼Ò¤ÏVHH¹³ÂΥӥ寥饤¥Ö¥é¥ê¤òÊÝͤ·¤Æ¤ª¤ê¡¢¥¨¥Ô¥È¡¼¥×ͽ¬¥¢¥ë¥´¥ê¥º¥à¤ò³«È¯¤·¤Æ¤¤¤Þ¤¹¡£¤³¤ì¤Ë¤è¤ê¡¢¥¦¥¤¥ë¥¹ÊÑ°Û¤ò²óÈò¤¹¤ëÊý¸þ¤Ç¥Ç¥¶¥¤¥ó¤·¡¢¥ª¥ß¥¯¥í¥ó½Ð¸½¤Î£±Ç¯°Ê¾åÁ°¤«¤é»Ô¾ì¤ËÄ󶡤·¤Æ¤Þ¤¤¤ê¤Þ¤·¤¿¡£Æȼ«³«È¯¤Î¥¢¥ë¥´¥ê¥º¥à¤Ë¤è¤ê¡¢¹ÈϰϤΥ¿¡¼¥²¥Ã¥Èʬ»Ò¤ËÂФ·¡¢¥æ¡¼¥¶¡¼¤ÎÌÜŪ¤Ë¤¢¤Ã¤¿µ©¾¯¤ÊÍÍÑ¥¯¥í¡¼¥ó¤ò¤´Ä󶡲Äǽ¤Ç¤¹¡£
CogNano¥Ó¥Ã¥°¥é¥¤¥Ö¥é¥êVHH¹³ÂÎ
¥é¥¯¥À²Êưʪ¡Ê¥é¥Þ¡¢¥¢¥ë¥Ñ¥«Åù¡Ë¤«¤é¸«½Ð¤µ¤ì¤¿½Åº¿¹³ÂÎͳÍè¹³¸¶·ë¹ç¥É¥á¥¤¥ó ¡ÊVHH¡¢Variable domain of Heavy chain of Heavy chain antibody¡Ë¤Ï ñÆȥɥᥤ¥ó¤Ç¹³¸¶·ë¹ç³èÀ¤ò»ý¤Á¡¢¹³¸¶Ç§¼±¤ÎÆðÛÀ¤¬Èó¾ï¤Ë¹â¤¤Ê¬»Ò¤Ç¤¹¡£ ʬ»ÒÎ̤Ï15kDa¤ÈIgG¹³ÂΤËÈæ¤Ù10ʬ¤Î1ÄøÅ٤Ⱦ®¤µ¤¯¡¢Ç®¤äpH¤Ê¤É¤ËÂФ·¹â¤¤°ÂÄêÀ¤ò»ý¤Á¡¢¥Ð¥¯¥Æ¥ê¥¢¤ÇÂçÎÌÀ¸»º²Äǽ¤Ç¤¹¡£²½³Ø½¤¾þ¤ä¹³ÂÎÌôʪʣ¹çÂΤؤΞ´¹¤¬ÍưפʤΤâÆÃħ¤Ç¤¹¡£
CogNano¥Ó¥Ã¥°¥é¥¤¥Ö¥é¥ê¤È¤Ï¡©
VHH¤ÎÃæ¤Ç¤âCogNano¥Ó¥Ã¥°¥é¥¤¥Ö¥é¥ê¤Ï¡¢Ì¤Ìȱ֡ʥʥ¤¡¼¥Ö¡Ë¤Î°äÅÁ»Ò¥¹¥È¥Ã¥¯¤ò»ÈÍѤ¹¤ë¤³¤È¤Ê¤¯¡¢Ãé¼Â¤Ê¥¿¥ó¥Ñ¥¯¼Á¥ï¥¯¥Á¥ó¤Ë¤è¤êÌȱ֤ò³ÍÆÀ¤·¤¿¥¢¥ë¥Ñ¥«¸ÄÂΤΰäÅÁ»Ò¤«¤éÃúÇ«¤Ë¼ùΩ¤·¤Þ¤¹¡£À¸Êª¤ÎÌȱÖǽÎϤˤè¤êºÇŬ²½¤·¤¿¿ôÀéËü¥¯¥í¡¼¥ó¤Î¥é¥¤¥Ö¥é¥ê¤«¤é¡¢CogNano¤¬³«È¯¤·¤¿¥¢¥ê¥´¥ê¥º¥à¤Ë¤è¤ê¸·Áª¤·¤¿É¸Åª·ë¹ç¥¯¥í¡¼¥ó¤ò¿¿ôÆÀ¤ë¤³¤È¤¬½ÐÍè¤ë¤Î¤Ç¡¢ÌÜŪ¤Ë¤¢¤Ã¤¿µ©¾¯¤Ê¥¯¥í¡¼¥ó¤ò¤´Ä󶡲Äǽ¤Ç¤¹¡£¤³¤ì¤Ë¤è¤êÁÏÌô¥·¡¼¥ººî½Ð¤Ë¤â°ÂÄꤷ¤¿¼ÂÀÓ¤¬¤¢¤ê¤Þ¤¹¡£
CogNano¼Ò
CogNano¼Ò¤Ï¡¢Æ°Êª¹³ÂΰäÅÁ»Ò¤Î¾ðÊó¿ÍͲ½¤òÍøÍѤ·¡¢NGS¡Ê¼¡À¤Â奷¡¼¥±¥ó¥¹¡Ë¤òÄ̤¸¤ÆµðÂç¥Ç¡¼¥¿¤ò¼èÆÀ¤·¤¿¤¦¤¨¡¢¥³¥ó¥Ô¥å¡¼¥¿²òÀϤò¹Ô¤¦¥×¥í¥°¥é¥à¡ÊAI¡Ë¤Ë¤è¤ëºÇŬ²½¤Þ¤Ç¤ò¥È¡¼¥¿¥ë¥µ¥Ý¡¼¥È¤Ç¤¤ë¡¢À¤³¦ºÇ¹â¿å½à¤ÎÈæÎà¤Ê¤¤VHH¹³ÂΥ᡼¥«¡¼¤Ç¤¹¡£
CogNano¥Ó¥Ã¥°¥é¥¤¥Ö¥é¥ê¤ÎÆÃħ
- ¹â¤¤ÆðÛÀ
- ¹â¤¤¿ÆÏÂÀ
- ¹³ÂΤι½Â¤¤¬¡Ê·Úº¿¤¬¤Ê¤¤¡Ë½Åº¿¹³ÂΡÊHCAb¡§Heavy chain-only antibody¡Ë¤Î¤¿¤á¡¢ºÇ¾®¡ÊÌó15kDa¡¢½¾Íè·¿¹³ÂΤΤ鷺¤«10ʬ¤Î1¤ÎÂ礤µ¡Ë¤Îµ¡Ç½Åª¹³¸¶·ë¹çÃÇÊÒ
- ʳ°¤ì¤¿°ÂÄêÀ
- ÈùÀ¸Êª¤Ç¤ÎÄ㥳¥¹¥ÈÀ¸»º
- ¥¢¥ë¥Ñ¥«¸ÄÂΤò»ÈÍѤ¹¤ë¤¿¤áÌȱֳÍÆÀ¤Ë¤è¤ëÇüÂç¤ÊɸŪ·ë¹ç¥¯¥í¡¼¥ó
- ¹â¤¤¥À¥¤¥Ð¡¼¥·¥Æ¥£¤ÇÊÑ°ÛÂбþÎϤ¬¤¢¤ë
- ¥Ð¥¤¥ª¤«¤é¥×¥í¥°¥é¥à¤Þ¤Ç°ì´Ó¤·¤¿À¸»º
- ¥¨¥Ô¥È¡¼¥×·èÄê²Äǽ¡Ê¥¯¥é¥¤¥ªÅŻҸ²Èù¶À¤Ë¤è¤ëÊ£¹çÂι½Â¤·èÄê¤ËÆüËܤǽé¤á¤ÆÀ®¸ù¡Ë
CogNano¥Ó¥Ã¥°¥é¥¤¥Ö¥é¥êVHH¹³ÂκîÀ®ÊýË¡
CogNano¥Ó¥Ã¥°¥é¥¤¥Ö¥é¥êVHH¹³ÂΤÎÈæ³Ó
¥â¥Î¥¯¥í¡¼¥Ê¥ë¹³ÂÎ | VHH¹³ÂÎ | |||
¥Ï¥ê¥Ö¥ê¥É¡¼¥ÞË¡ | ´µ¼ÔͳÍèlgG¥¯¥í¡¼¥ó | ¥Ê¥¤¡¼¥Ö¥é¥¤¥Ö¥é¥ê ¡ÊVHH¡Ë |
COGNANO ¥Ó¥Ã¥°¥é¥¤¥Ö¥é¥ê¡ÊVHH¡Ë |
|
ÌȱÖÀ¸Êª | ¤²¤Ã»õÎà | ¥Ò¥È¡Ê´µ¼Ô¡Ë | µ¾À·¥é¥¯¥À°äÅÁ»Ò¥¹¥È¥Ã¥¯ | ¥¢¥ë¥Ñ¥«¸ÄÂÎ |
´ü´Ö | 2¡Á3¥ö·î | 1¡Á2¥ö·î | ¤Ê¤· | 3¥ö·î°Ê¾å |
¹³¸¶ | ¥¿¥ó¥Ñ¥¯¼Á | ¥¦¥¤¥ë¥¹É¸¶ÂÎ | ¤Ê¤· | ¥¿¥ó¥Ñ¥¯¼Á |
¥Õ¥¡¡¼¥¸¥Ñ¥Ë¥ó¥°¥Ù¥¤¥È | ¤Ê¤· | ¤Ê¤· | ¥¿¥ó¥Ñ¥¯¼Á | ¥¿¥ó¥Ñ¥¯¼Á |
ɸŪ·ë¹ç¥¯¥í¡¼¥ó¿ô | 500¡Á1000 | 500¡Á1000 | ¡Á10 | ¿ôÀéËü |
¥·¡¼¥º³ÍÆÀ¿ô ¡Ê¿··¿¥³¥í¥Ê¤Î¾ì¹ç¡Ë |
¿ô½½¡Á¿ôÉ´¥¹¥±¡¼¥ë | ¿ô½½¡Á¿ôÉ´¥¹¥±¡¼¥ë | ¿ô¸Ä | ¿ôÉ´Ëü¸Ä |
¹³ÂÎÇÛÎó | ¥¯¥í¡¼¥ó¤¢¤¿¤ê ²òÆɤË2¥ö·î |
¥¯¥í¡¼¥ó¤¢¤¿¤ê ²òÆɤË2¥ö·î |
´ûÆÀ | ´ûÆÀ |
¼¡À¤Â奷¡¼¥±¥ó¥¹ | ÉÔÍ× | ÉÔÍ× | ÉÔÍ× | ɬ¿Ü |
¥À¥¤¥Ð¡¼¥·¥Æ¥£ | ¾¯ | Ãæ | ¾¯ | ¿ |
AI¥¹¥¯¥ê¡¼¥Ë¥ó¥° | ¤Ê¤· | ¤Ê¤· | ¸õÊ䤬¾¯¤Ê¤¤¤Î¤ÇÉÔÍ× | ¸õÊ䤬¿¤¤¤Î¤ÇɬÍ× |
·ë¹çÎÏ | ¹â | ¹â | Ãæ | ¹â |
¥¨¥ó¥¸¥Ë¥¢¥ê¥ó¥°²ÄǽÀ | ¾¯ | ¾¯ | Âç | Âç |
ÊÑ°ÛÂбþÎÏ | ¤Ê¤· | ¤Ê¤· | ¤Ê¤· | ¤¢¤ê |
CryoEM¤Ë¤è¤ë ¥¨¥Ô¡¼¥Ö·èÄê |
º¤Æñ¡ÊFab²½ Í×¡Ë | º¤Æñ¡ÊFab²½ Í×¡Ë | Èæ³ÓŪÍÆ°× | Èæ³ÓŪÍÆ°× |
VHH¹³ÂΥ饤¥Ö¥é¥ê¡¼¤ÎÎã
category | immunogen(¹³¸¶¡Ë | target molecule(ɸŪʬ»Ò¡Ë |
Albumin | HSA | Human serum albumin |
LSA | Lyama serum albumin | |
Chromatin | HP1 | Chromatin protein |
Cytokine | IL6 | Human interleukin-6 |
TNFa | Human tumor necrosis factor alpha | |
GPCR | CXCR1 | Chemokine receptor |
CXCR2 | Chemokine receptor | |
CXCR4 | Chemokine receptor | |
GPRC5b | Orphan receptor | |
GPRC5c | Orphan receptor | |
CaSR | Calcium sensing receptor | |
CCR5 | Chemokine receptor | |
b2AR | Adrenaline receptor | |
OPRd1 | Opioid receptor | |
OPRk1 | Opioid receptor | |
OPRm1 | Opioid receptor | |
HTR1B | Histamine receptor | |
HTR2B | Histamine receptor | |
GMR1 | Glutamine receptor | |
GMR5 | Glutamine receptor | |
CHRNA1 | Cholinergic Receptor Nicotinic Alpha I | |
CHR3M | acetylcholine receptor | |
CHR4M | acetylcholine receptor | |
b1AR | Adrenaline receptor | |
Immunoglbulin | hIgG | Human IgG |
bIgG | Bovine IgG | |
Membrane protein | hTsp1 | Human Tetraspanin 1 |
hTsp4 | Human Tetraspanin 4 | |
hTsp8 | Human Tetraspanin 8 | |
Receptor | Her2 | EGF receptor 2 |
hOX40 | Human OX40 | |
fOX40 | Feline OX40 | |
hCD4 | Human CD4 | |
Sugar | MUC1-Tn | Tn-Type glycan |
MUC1-STn | Sialyl Tn-type glycan | |
Virus | HIV Env | HIV Envelope protein |
Ebora Env | Ebora Envelope protein | |
FIV vaccine | Feline Immunodeficiency virus | |
RV vaccine | Rabies virus |
designing & optimization VHH-applied CAR-T vector
¤´¶½Ì£¤Î¤¢¤ëVHH¤´¤¶¤¤¤Þ¤·¤¿¤é¡¢ÊÀ¼Ò¤Þ¤Ç¤ªÌä¹ç¤»¤¯¤À¤µ¤¤¡£
ʸ¸¥
YOUTUBE
CogNano¼ÒWeb
CogNano Tech Blog
CogNano Tech Blog¤Î¶½Ì£¿¼¤¤ÆâÍƤòÆȼ«¤Ë¥Ô¥Ã¥¯¥¢¥Ã¥×¡ª
- https://cognano.hatenablog.com/entry/2022/07/19/104514
- https://cognano.hatenablog.com/entry/2022/05/09/100646
¡Ö¥¢¥ë¥Ñ¥«¹³ÂΡפ˴ؤ¹¤ëÏÀʸ²òÀâ¤ÈCOGNANO¤Ï¤â¤¦IT¥Æ¥Ã¥¯¤Ë¤Ê¤Ã¤Æ¤¤¤Þ¤¹¡¢¤Î·ï
¥Ð¥¤¥ª¥Æ¥Ã¥¯COGNANO¤Î¿·CTO¤¬IT¥¨¥ó¥¸¥Ë¥¢¤Ç¤¢¤ëÍýͳ